The transport and localization of benzo(a)pyrene-hematite and hematite-210Po in the hamster lung following intratracheal instillation.

lung tumors of different histologies and apparent sites of origin. Hematite-210Po produces combined epidermoid and adenocarcinomas in the peripheral lung, while BP-hematite produces mainly epidermoid carcinomas of the major bronchi and trachea. To determine whether cells in the lung are differentially sensitive to the two types of carcinogen or whether the carcinogens are reaching and acting at different sites, we have studied their transport and localization following intratracheal administration on carrier particles: 210Polocalization by freeze-dry autoradiography and BP by